The Role of Protein Lactylation in Skin Diseases: From Molecular Mechanisms to Potential Therapeutics

The document reviews the role of protein lactylation, a post-translational modification, in skin diseases and its potential as a therapeutic target. Lactylation influences various skin processes, including inflammation, collagen synthesis, and immune response modulation, impacting conditions like psoriasis, atopic dermatitis, and melanoma. It acts as a molecular bridge linking metabolism and epigenetic regulation, affecting skin physiology and disease pathogenesis. The review suggests that targeting lactylation could enhance treatment efficacy, particularly in patients with metabolic disorders, though further research is needed to validate these findings and assess the safety of lactate inhibitors in clinical settings.