Enhancing Quercetin Bioavailability Attenuates Aging Phenotypes Via the Gut Microbiota–Intestinal Barrier Axis in Aged Mice

This study demonstrates that enhancing quercetin bioavailability using EubioQuercetin (EQN) significantly reduces aging phenotypes in aged mice, as evidenced by a lower aging score compared to controls. EQN treatment led to beneficial changes in gut microbiota composition, suppressing taxa associated with aging and promoting those linked to a healthier profile. Additionally, EQN modulated intestinal gene expression by downregulating senescence-associated genes and upregulating the tight junction gene claudin-1. These results suggest that the gut microbiota–intestinal barrier axis plays a crucial role in the anti-aging effects of quercetin.