Enhancing Quercetin Bioavailability Attenuates Aging Phenotypes Via the Gut Microbiota–Intestinal Barrier Axis in Aged Mice
May 2026
in “
Nutrients
”
TLDR Improving quercetin absorption reduces aging signs in mice by benefiting gut health.
The study examined the effects of EubioQuercetin (EQN), a highly bioavailable form of quercetin, on aging phenotypes in 28 aged male mice, focusing on the gut microbiota–intestinal barrier axis. EQN significantly improved external aging signs, such as hair glossiness and reduced hair loss, compared to conventional quercetin (CQN) and control groups. It altered gut microbiota composition by reducing aging-associated bacteria and enhancing beneficial ones, and improved intestinal barrier integrity by modulating gene expression. These findings suggest that enhancing quercetin bioavailability through EQN can attenuate aging phenotypes by modulating gut health, although further research is needed to explore its potential in humans.
