Raman Investigation of In Vivo Radiation Exposure on Melanin in Murine Hair

    March 2025 in “ PNAS Nexus ”
    Monika Poonia, Spencer A. Witte, Martin J. Woodward, Prasant Yadav, Sapna Puri, Ramasamy Santhanam, Naduparambil K. Jacob, Zachary D. Schultz
    TLDR Raman spectroscopy can detect radiation exposure in mouse hair with high accuracy for up to 7 days.
    This study explores the use of Raman spectroscopy to assess changes in melanin from the hair of C57BL/6 mice exposed to gamma radiation, ranging from 0 to 4 Gy. The research identifies melanin-specific Raman features as potential biomarkers for radiation exposure, with a 785-nm excitation wavelength showing greater sensitivity. The study achieved 88% sensitivity and 83% specificity in distinguishing irradiated from nonirradiated mice, with 100% accuracy up to 7 days post-exposure. However, accuracy declined after 7 days due to changes in melanin spectra. The method allows for precise dose estimation with <1 Gy precision and holds promise for noninvasive radiation biodosimetry and medical monitoring.
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