Rational Design of Human Hair Keratin-Driven Proteins for Hair Growth Promotion

August 2024 in “ Advanced Healthcare Materials ”

Haojie Zhang, Rui Qing, Wenfeng Li, Yuhan Yuan, Yinping Pan, Ni Tang, Qiulan Huang, Li Wang, Shilei Hao

recombinant keratins RK31 RK81 keratin extracts microneedles hair follicles hair growth keratin

TLDR RK81 can help promote hair growth.

The study investigates the use of water-soluble recombinant keratins (RKs) K31 and K81, designed through QTY Code methodology, to promote hair growth. The researchers found that more than 40% of hair follicles in the RK81QTY group entered the anagen phase by day 12, with new hair diameters averaging 15.10 ± 2.45 µm, indicating significant hair growth and improved hair quality compared to RK31QTY. The water-soluble RKs enhanced hair follicle activity and robust hair regeneration more effectively than keratin extract and minoxidil by upregulating the PI3K/AKT/Nf-κB signaling pathway. These results suggest that solubilized recombinant keratins could be a promising therapeutic approach for hair growth. The authors declare no conflict of interest.

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