Hair Growth Promoting Activity of Discarded Biocomposite Keratin Extract

    June 2017 in “ Journal of Biomaterials Applications ”
    Rashedunnabi Akanda, Hee Young Kim, Soo‐Jin Park, In‐Shik Kim, Dongchoon Ahn, Hyun‐Jin Tae, Byung‐Yong Park
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    TLDR Keratin extract from human hair was found to promote hair growth in mice.
    The 2017 study demonstrated that keratin extract (KE) derived from discarded human hair promotes hair growth in C57BL/6 mice. The topical application of KE induced the anagen phase of hair follicles, increased the number and shaft of hair follicles, and expanded the deep subcutis area. KE was found to be biocompatible, with over 90% cell viability in human keratinocyte cells. It also upregulated the expression of growth factors and proteins such as FGF-10, VEGF, IGF-I, ß-catenin, and Shh, which are crucial for hair follicle development. The study concluded that KE could be a promising treatment for hair follicle disorders. The in vivo portion of the study involved 48 mice, divided into two groups, while the in vitro tests used HaCaT cells with KE concentrations of 25, 50, and 100 µg/ml.
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