Case of Recessive Dystrophic Epidermolysis Bullosa-Mitis Diagnosed in Older Age

    July 2023 in “ Media Dermato Venereologica Indonesiana ”
    Inadia Putri Chairista, Shannaz Nadia Yusharyahya, Lili Legiawati, Rahadi Rihatmadja, Rinadewi Astriningrum
    TLDR Accurate diagnosis of RDEB-mitis in older adults is crucial for proper management without immunosuppressants.
    The article discusses a case of Recessive Dystrophic Epidermolysis Bullosa (RDEB) in a 67-year-old male, highlighting the challenges in diagnosing the mitis variant in older adults. RDEB is a rare genetic condition caused by mutations in the COL7A1 gene, leading to skin fragility. The patient presented with blisters and wounds that worsened over the past year, with symptoms such as vesicles, bullae, and atrophic scars. Histopathological examination revealed subepidermal clefting without immunoglobulin deposits, distinguishing it from autoimmune conditions like epidermolysis bullosa acquisita. The study emphasizes the importance of accurate diagnosis, as RDEB-mitis does not require immunosuppressants, and management focuses on minimizing trauma to prevent complications.
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