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GlossarySkin Fragility

condition where skin is unusually delicate and easily damaged

Skin fragility refers to a condition where the skin is unusually delicate and prone to damage, such as tearing, blistering, or bruising, even with minimal trauma. This can be due to genetic disorders, aging, or underlying medical conditions that affect the structural integrity of the skin, such as Ehlers-Danlos syndrome or certain types of epidermolysis bullosa. For professionals, understanding the underlying cause is crucial for managing and treating the condition effectively.

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Research

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research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations , August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

research Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis

8 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A boy's skin fragility and sparse hair were caused by a genetic mutation affecting skin cell adhesion.

research 474 Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility

April 2017 in “Journal of Investigative Dermatology”

Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.

research Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ

December 2016 in “Experimental and Molecular Pathology”

Mus pahari mice have fragile skin due to abnormal collagen and elastin.

research Skin fragility, diffuse ecchymosis and blisters on a yellowish waxy base

April 2016 in “Journal of The American Academy of Dermatology”

A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.

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community Started balding at 20, tried everything, gave up. Then got a custom hair piece & it helped me embrace being bald! AMA

in Hair Systems 488 upvotes 3 years ago

A user who started balding at 20 trying different treatments to combat hair loss before eventually embracing being bald and getting a custom hair piece as an option. Various people commented on his looks with and without the wig, generally agreeing that he looked better bald.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 21 upvotes 1 year ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Here is the video of Dr. Koray Erdoğan's hair transplant operation from start to finish. The long version of this video will be on our YouTube channel soon.

in Transplants 460 upvotes 2 years ago

The conversation is about a hair transplant operation video by a clinic owner, with comments suggesting it's staged for marketing and criticizing the unrealistic hairline created. Some users question the necessity of the transplant for the individual featured.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 4 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community HairClone developing cell replacement treatments for Hair Loss

7 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

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Learn

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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

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