TLDR Enhancing regulatory T cells may help treat autoimmune diseases like alopecia areata.
The document discussed the role of regulatory T cells in autoimmune diseases, particularly alopecia areata (AA), where hair follicles are attacked by CD4+ and CD8+ lymphocytes. It highlighted the importance of regulatory cell subsets, such as CD4+/CD25+ cells, in maintaining immune tolerance and preventing autoimmunity. In the C3H/HeJ mouse model, a reduction in these regulatory cells was linked to AA susceptibility. In humans, an increase in CD4+/CD25+ cells was observed during active AA, but these cells showed impaired regulatory function. The study suggested that enhancing the function of regulatory T cells and reducing apoptosis resistance in pathogenic cells could be potential therapeutic strategies for AA.
38 citations
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September 2004 in “Journal of Autoimmunity” Alopecia areata patients have more activated T cells in their blood, which may help in developing treatments.
77 citations
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June 2002 in “Journal of Investigative Dermatology” CD44 variant changes start alopecia areata, but don't maintain it.
4 citations
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October 2022 in “Genes” Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.
May 2018 in “White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)” Alopecia areata may be treated by using EGCG to balance immune cells and reduce inflammation.
1 citations
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January 2025 in “Genes & Diseases” Understanding T cells and signaling pathways can lead to better treatments for hair loss.
60 citations
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September 2015 in “Expert Review of Clinical Immunology” Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
62 citations
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June 2015 in “The Journal of Dermatology” People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.
