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    GlossaryImmune Tolerance

    process where immune system avoids attacking body's own cells

    Immune tolerance is the process by which the immune system learns to recognize and not attack the body's own cells and tissues. This is crucial for preventing autoimmune diseases, where the immune system mistakenly targets the body's own cells, such as in alopecia areata where hair follicles are attacked. For professionals, it involves mechanisms like central tolerance in the thymus and peripheral tolerance in other tissues to maintain self-tolerance and prevent autoimmunity.

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      JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

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      community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

      in Chat  15 upvotes 2 years ago
      A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

      community Hair Loss “Cure” for Inflammation: Topical Roflumilast

      in Research/Science  32 upvotes 2 months ago
      Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

      community After 1.5 years+ on dut/fin hairless has finally slowed!

      in Finasteride/Dutasteride  77 upvotes 5 years ago
      After 1.5 years on finasteride and dutasteride with continued hair loss, the user noticed a significant reduction in hair shedding, attributing it to the consistent use of finasteride, along with a no-shampoo approach, multivitamins, vitamin D, and restarting minoxidil. Other users shared their happiness for the improvement and noted that hair loss can fluctuate naturally over time.