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GlossaryImmune Tolerance

process where immune system avoids attacking body's own cells

Immune tolerance is the process by which the immune system learns to recognize and not attack the body's own cells and tissues. This is crucial for preventing autoimmune diseases, where the immune system mistakenly targets the body's own cells, such as in alopecia areata where hair follicles are attacked. For professionals, it involves mechanisms like central tolerance in the thymus and peripheral tolerance in other tissues to maintain self-tolerance and prevent autoimmunity.

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Research

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Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance

1 citations , October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

research Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance

March 2026 in “Frontiers in Medicine”

Different types of alopecia cause hair loss due to immune system issues, with some allowing regrowth and others causing permanent loss.

research Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth

January 2025 in “ACS Applied Materials & Interfaces”

Nanoparticles with specific drugs can help regrow hair in alopecia areata.

Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–Like Autoimmune Disease

research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–like Autoimmune Disease

26 citations , June 2018 in “The journal of immunology/The Journal of immunology”

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

research Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasis

2 citations , June 2026 in “Frontiers in Science”

Regulatory T cells help control the immune system and could lead to new treatments for diseases.

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Community Join

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community Is it okay to use topical fin/min immediately after dermastamping?

in Microneedling 26 upvotes 2 years ago

The conversation discusses the timing of applying Minoxidil and finasteride after microneedling. Opinions vary, with some suggesting immediate application and others recommending waiting to avoid skin irritation.

community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 6 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community Han Bio claims success at Hair Multiplication

in Research/Science 20 upvotes 5 years ago

Han Bio claims success in hair multiplication using dermal papilla cells. Treatments discussed include Minoxidil, finasteride, and RU58841.

community After 1.5 years+ on dut/fin hairless has finally slowed!

in Finasteride/Dutasteride 77 upvotes 5 years ago

After 1.5 years on finasteride and dutasteride with continued hair loss, the user noticed a significant reduction in hair shedding, attributing it to the consistent use of finasteride, along with a no-shampoo approach, multivitamins, vitamin D, and restarting minoxidil. Other users shared their happiness for the improvement and noted that hair loss can fluctuate naturally over time.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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