Human Scalp Hair Follicles Are Protected From Alopecia Areata In Vivo By Regulatory γδT Cells

This study investigates the role of Foxp3+γδTregs in protecting human scalp hair follicles from alopecia areata (AA) using a humanized mouse model. The research demonstrates that γδTregs, when injected into xenografts, can prevent AA lesion formation and promote hair regrowth by restoring hair follicle immune privilege and reducing perifollicular infiltrations. The protective effects of γδTregs are mediated by IL-10 and TGF-β1, as neutralizing these cytokines reverses the ameliorating effects on AA. The findings suggest that γδTregs could serve as a novel cell-based therapy for treating AA.