Targeted Determination of Residual Sex Hormones in Cosmetics Using Magnetic Solid-Phase Extraction with Isotope-Labeled Internal Standards by UHPLC-MS/MS

    December 2025 in “ Molecules ”
    Yalei Dong, Shuyan Sun, Yasen Qiao, Chunhui Yu, Haiyan Wang, Lei Sun
    TLDR A new method effectively detects trace sex hormones in cosmetics, ensuring safety.
    The study developed a reliable method using UHPLC-MS/MS with magnetic solid-phase extraction and isotope-labeled internal standards to detect trace sex hormones in cosmetics, addressing safety concerns. The method was validated with recoveries between 71.7-116.2% and RSDs from 1.6% to 8.3%. Analysis of 116 cosmetic batches revealed trace progestins and estrogens in 10 samples. The method proved convenient, efficient, and environmentally friendly, scoring 0.66 on the AGREE metric. A preliminary safety evaluation assessed potential health risks of residual progesterone in hair loss prevention cosmetics by calculating the margin of safety.
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