Translating Resveratrol Research: A Systematic Review on Patents and Clinical Trials (2000–2025)

This systematic review examines the therapeutic potential of resveratrol (RSV) from 2000 to 2025, highlighting its benefits in managing chronic conditions like diabetes, cardiovascular diseases, and certain cancers. Despite promising antioxidant, anti-inflammatory, and anticancer properties, RSV's clinical use is limited by poor bioavailability and rapid metabolism. The review analyzed 162 studies and noted innovative delivery methods, such as nanocarriers, to enhance efficacy. RSV derivatives show promise in cancer treatment, prostate health, and metabolic diseases. While RSV demonstrates potential in various health conditions, variability in outcomes and regulatory challenges persist, necessitating further research to optimize its clinical application.