The Use of a Retinoid Receptor Antagonist in a New Model to Study Vitamin A-Dependent Developmental Events

May 1998 in “ PubMed ”

D. M. Kochhar, H. Jiang, J.D. Penner, A. T. Johnson, R A Chandraratna

retinoic acid retinoic acid receptor antagonist AGN 193109 RAR retinoid receptor vitamin A skin development hair follicle development

TLDR The retinoid receptor antagonist effectively disrupts vitamin A-related development in embryos.

The study explored the role of retinoic acid in development by using a retinoid receptor antagonist, AGN 193109, to interfere with retinoic acid receptor functions at specific developmental stages in mice. A single dose of the antagonist on day 8 post coitum caused severe craniofacial and eye malformations in nearly all fetuses, while treatment on day 11 did not affect limb development, even at high doses. Additionally, administration on day 14 delayed skin and hair follicle maturation. This model was deemed effective for investigating the functions of retinoic acid and its receptors in embryogenesis and adult animals.

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research The Use of a Retinoid Receptor Antagonist in a New Model to Study Vitamin A-Dependent Developmental Events

44 citations , May 1998 in “PubMed”

The retinoid receptor antagonist effectively disrupts vitamin A-related development in embryos.