TLDR Invasomes with natural terpenes can improve drug delivery through the skin.
The document reviewed the use of invasomal carriers incorporating natural terpenes for enhanced transdermal drug delivery. It highlighted the role of terpenes like menthol, limonene, linalool, and cineole in disrupting the skin's lipid structure to increase drug permeation. Invasomes, composed of phospholipids, terpenes, and ethanol, demonstrated superior skin penetration compared to traditional liposomes, with smaller vesicles penetrating deeper. Studies showed that invasomes improved the bioavailability and penetration of drugs for various conditions, including acne, breast cancer, erectile dysfunction, and alopecia. For alopecia, elastic vesicles with cineole enhanced minoxidil delivery, while finasteride invasomes with limonene showed the highest enhancement in rat skin. The document concluded that invasomes and flexible vesicular systems offered promising advancements in transdermal drug delivery strategies.
35 citations
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January 2014 in “Postepy Dermatologii I Alergologii” DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.
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July 2009 in “International Journal of Pharmaceutics” PEVs improve minoxidil skin penetration, increasing hair growth.
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128 citations
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July 2009 in “International Journal of Pharmaceutics” PEVs improve minoxidil skin penetration, increasing hair growth.
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August 2020 in “Drug Design Development and Therapy” Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.
