A State-Of-The-Art Review On Recent Biomedical Application Of Polysaccharide-Based Niosomes As Drug Delivery Systems

This review explores the advancements in polysaccharide-based niosomes as drug delivery systems, emphasizing their versatility and potential in various biomedical applications. Niosomes offer benefits such as improved chemical stability, cost-effectiveness, and enhanced drug delivery across ocular, oral, nose-to-brain, pulmonary, cardiac, and transdermal routes. They are particularly effective in cancer therapy, enabling precise drug release at tumor sites, and in reducing cardiotoxicity. Polysaccharides enhance niosomes' biocompatibility, biodegradability, and antibacterial properties, making them superior to other polymers. The review also highlights specialized niosome types like polyhedral niosomes, proniosomes, and elastic niosomes, each offering unique advantages in drug delivery. Despite their potential, challenges such as manufacturing scalability and stability need addressing for clinical translation. Future research directions include integrating stimuli-responsive materials and conducting clinical studies for personalized therapy.