A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing

    February 2024 in “ Cureus ”
    Milind R Gharpinde, Aditya Pundkar, Sandeep Shrivastava, Hardik Patel, Rohan Chandanwale
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    TLDR Platelet-rich plasma can speed up bone healing and shows promise in orthopaedic treatments.
    This review explores the role of platelet-rich plasma (PRP) in accelerating bone healing, highlighting its regenerative potential due to its rich composition of platelets and growth factors. PRP's mechanisms include releasing growth factors, chemotaxis, and angiogenesis, which contribute to its effectiveness in fracture healing and orthopaedic surgeries. The review emphasizes the promising outcomes of clinical trials, while also addressing safety considerations, patient selection, and the need for standardisation in PRP preparation and application. Future prospects for PRP in bone healing include precision medicine, integration with emerging therapies, and expanded applications, particularly in orthopaedics and regenerative medicine.
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