Pathogenetic Rationale for the Use of Exosomes Derived from Salmon Tissue in Patients with Androgenetic Alopecia: A Prospective Uncontrolled Observational Study

This study examined the use of salmon-derived exosomes combined with microneedling in 20 patients with androgenetic alopecia (AGA) over 12 weeks. Results showed significant improvements in hair density (+44.4 hairs/cm²), hair shaft diameter (+22.4 µm), and an increase in anagen phase hairs (+36.4%). The treatment also reduced vellus hairs from 40.4% to 3.4% and improved the terminal/vellus hair ratio, suggesting a reversal of hair miniaturization. Immunohistochemical analysis indicated increased cell proliferation and angiogenesis, with no serious adverse effects. While these findings are promising, further randomized controlled trials are necessary to confirm the treatment's efficacy and compare it with traditional methods.