Evaluation of the Cosmetic Efficacy of Salmon Tissue-Derived Exosomes and Plasmatherapy in Patients with Androgenetic Alopecia: A Randomized Controlled Clinical Trial

May 2026 in “ Russian Journal of Skin and Venereal Diseases ”

Olga Olisova, Vera Smolyannikova, Karim Karray, Anfisa Lepekhova

salmon tissue-derived exosomes plasmatherapy androgenetic alopecia platelet-rich plasma hair density terminal/vellus hair ratio anagen proportion hair diameter exosomes PRP

TLDR Salmon tissue-derived exosomes improve hair growth better than platelet-rich plasma for treating hair loss.

This randomized controlled clinical trial assessed the efficacy of salmon tissue-derived exosomes and plasmatherapy (PRP) in treating androgenetic alopecia in 40 patients. Participants were divided into two groups, with one receiving exosome treatment and the other PRP. The study found that both treatments significantly improved hair density, but the exosome group showed superior results, with hair density increasing from 102.6 to 147.0 hairs/cm² compared to 101.8 to 128.1 hairs/cm² in the PRP group. Additionally, the exosome group experienced greater improvements in anagen hair percentage, hair diameter, and a reduction in vellus hair percentage. These results suggest that salmon tissue-derived exosomes may be a more effective treatment option for enhancing hair growth in patients with androgenetic alopecia.

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research Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources

September 2025 in “Clinical Cosmetic and Investigational Dermatology”

Exosome therapy shows promise for hair growth with minimal side effects, but more research is needed.

research Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment

August 2025 in “Drug Design Development and Therapy”

Current treatments for androgenetic alopecia are complex and promising, but more research is needed.

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway

research Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway

August 2025 in “Stem Cell Research & Therapy”

Exosomes from stem cells can help regrow hair better than minoxidil.

research Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway

April 2025 in “Regenerative Therapy”

Platelet-rich plasma-derived exosomes can help regrow hair by activating a specific signaling pathway.

A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia

research A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia

March 2025 in “Life”

The plant extract helped increase hair growth in men without severe side effects.

Exploring the Efficacy and Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Androgenic Alopecia

research Exploring the Efficacy and Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Androgenic Alopecia

August 2024

Mesenchymal stem cell-derived exosomes significantly increase hair density and thickness in androgenic alopecia patients.

research The Role of Exosomes in the Diagnosis and Treatment of Immune Mediated Dermatosis, Treatment of Skin Wounds and Alopecia

April 2024 in “Vestnik dermatologii i venerologii”

Exosomes show promise for diagnosing and treating skin conditions and hair loss.

research Diagnosis and Differential Diagnosis of Tertiary Androgenetic Alopecia With Severe Alopecia Areata Based on High-Resolution MRI

June 2023 in “Skin Research and Technology”

High-resolution MRI can distinguish between tertiary androgenetic alopecia and severe alopecia areata by measuring scalp and tissue thickness and hair follicle depth.