Efficacy of Scalp Cooling System Versus Chemical Cooling Cap in Preventing Chemotherapy-Induced Alopecia in Breast Cancer: A Prospective Randomized Trial

The COHAIR study evaluated the effectiveness of a scalp cooling system versus a chemical cooling cap in preventing chemotherapy-induced alopecia in 152 breast cancer patients. Both methods showed similar hair preservation success rates, with 74.5% for the scalp cooling system and 71.2% for the chemical cooling cap. The chemical cooling cap was associated with lower anxiety and better quality of life, despite the scalp cooling system showing superior early efficacy during anthracycline treatment. Both interventions were well-tolerated, and disease-free survival was comparable between the groups. The study suggests that patient comfort and psychological outcomes are important considerations in choosing CIA prevention methods.