Serum Betatrophin and Irisin Levels in Patients with Polycystic Ovary Syndrome with and without Insulin Resistance

This study investigated the levels of irisin and betatrophin in 60 women divided into three groups: PCOS, PCOS with insulin resistance (PCOS+IR), and controls. The results showed that irisin levels were significantly higher in the PCOS+IR group, while betatrophin levels were significantly lower in both PCOS groups compared to controls. Irisin was positively correlated with body mass index (BMI), but betatrophin showed no significant correlation with BMI. The study concluded that irisin and betatrophin exhibit distinct and independent alterations in PCOS, suggesting their potential role in enhancing metabolic phenotyping and risk assessment for the condition.