Serum and Hair Steroid Profiles and Their Associations with Body Composition in Adolescence

November 2025 in “ Open Access CRIS of the University of Bern ”

Liimatta, Jani, Huotari, Johanna, du Toit Therina, Fluck Christa E, Jääskeläinen, Jarmo, Hackney, Anthony C., Häkkinen, Merja R, Lehtonen Marko, Auriola Seppo, Lakka, Timo A., Voutilainen, Raimo

steroid hormone profiles pregnenolone cortisone cortisol androgens peripheral metabolism androgen levels hair steroid profiling serum analysis systemic hormone levels metabolic activity

TLDR Androgen levels are more linked to body size in boys than girls.

This study compared serum and hair steroid hormone profiles in 241 adolescents (104 girls, 137 boys) from the PANIC study in Finland, focusing on their associations with body size and composition. Hair samples showed distinct steroid profiles, including pregnenolone and various androgens, indicating active peripheral metabolism. Androgen levels correlated more strongly with body size and composition in boys than girls, suggesting sex-specific metabolic regulation. The findings suggest that hair steroid profiling is a feasible, non-invasive alternative to serum analysis, capturing systemic hormone levels and localized metabolic activity, with potential applications in clinical endocrinology pending further validation.

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