Correlation Between Increased Total Serum IgE Levels and Clinical Features in Alopecia Areata Patients

June 2025 in “ Frontiers in Immunology ”

Yijie Sun, Shuang Xu, Yujing Zhang, Yuxin Wang, Jianzhong Zhang, Xiangqian Li, Cheng Zhou

alopecia areata total serum IgE Th2 cytokines AA

TLDR Higher IgE levels may play a role in alopecia areata, especially in males, children, and severe cases.

The study found that total serum IgE levels are elevated in patients with alopecia areata (AA) compared to a control group. Notably, male patients, children, and those with moderate to severe AA exhibited significantly higher IgE levels. These findings indicate a potential role of IgE and Th2 cytokines in the pathogenesis of AA.

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