Dupilumab Therapy for Alopecia Areata: A Case Series and Review of the Literature

February 2024 in “ Journal of Dermatological Treatment ”

Jundong Huang, Jian Jia, Tingting Li, Min Li, Luo Kaifu, Sihan Deng, Yan Tang, Fangfen Liu, Zhixiang Zhao, Wei Shi, Ji Li

TLDR Dupilumab may help treat alopecia areata without needing high IgE levels.

The research indicates that dupilumab shows potential benefits as a treatment for alopecia areata (AA). Importantly, the study suggests that high levels of IgE are not necessary for a successful treatment response with dupilumab, broadening its applicability for patients with AA.

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Research cited in this study

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research Drug Survival and Long-Term Outcome of Tofacitinib in Patients with Alopecia Areata: A Retrospective Study

2 citations , November 2023 in “Acta dermato-venereologica”

Tofacitinib is effective and safe for treating alopecia areata with a good drug survival rate.

research Treatments for Moderate-to-Severe Alopecia Areata: A Systematic Narrative Review

1 citations , October 2023 in “Dermatology and therapy”

Some treatments for severe hair loss work but often have side effects, with baricitinib showing the most promise.

research Dupilumab Therapy for Alopecia Areata in a 4-Year-Old Patient Resistant to Baricitinib

October 2023 in “Frontiers in Medicine”

Dupilumab helped a 4-year-old grow hair back after another treatment failed.

research Alopecia Areata: The Clinician and Patient Voice

1 citations , September 2023 in “Journal of drugs in dermatology”

Alopecia areata causes unpredictable hair loss and emotional distress, with no cure and limited treatment options.

research Janus Kinase Inhibitors For Alopecia Areata

12 citations , June 2023 in “JAMA network open”

JAK inhibitors effectively improve hair regrowth in alopecia areata with an acceptable safety profile.

research Allergen desensitization reduces the severity of relapsed alopecia areata in dust‐mite allergic patients

9 citations , April 2023 in “Experimental Dermatology”

research The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity

10 citations , January 2023 in “Journal of the European Academy of Dermatology and Venereology”

Alopecia areata greatly affects people's life quality, mental health, and work life.

research Scalp Biomarkers During Dupilumab Treatment Support Th2 Pathway Pathogenicity in Alopecia Areata

15 citations , October 2022 in “Allergy”

Dupilumab treatment reduces Th2-related markers and helps hair growth in alopecia areata, showing Th2's role in the condition.

research The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies

37 citations , August 2022 in “Frontiers in pharmacology”

Oral JAK inhibitors are effective and safe for treating alopecia areata but may need ongoing use to keep results.

research Dupilumab for Alopecia Areata Treatment: A Double-Edged Sword?

2 citations , June 2022 in “Journal of cosmetic dermatology”

Dupilumab can help hair regrowth but may also trigger alopecia areata.

research Alopecia Areata: Current Understanding and Management

11 citations , January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft”

Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.

research Improvement of Atopic Dermatitis and Alopecia Universalis with Dupilumab: A Case Report

3 citations , December 2021 in “Dermatology reports”

Dupilumab can improve both atopic dermatitis and alopecia universalis.

research Time to Loss of Response for Dupilumab in Ophiasis-Pattern Alopecia Areata

2 citations , September 2021 in “JAAD case reports”

Dupilumab helped a woman with severe hair loss regrow her hair quickly and maintain it for six months after stopping treatment.

research Dupilumab for the Treatment of Alopecia Areata in Children with Atopic Dermatitis

7 citations , July 2021 in “JAAD case reports”

Dupilumab may help treat alopecia areata in children with atopic dermatitis, but it can also cause new hair loss.

research Dupilumab Therapy for Alopecia Areata in Pediatric Patients with Concomitant Atopic Dermatitis

19 citations , January 2021 in “Journal of the American Academy of Dermatology”

Dupilumab may help children with alopecia areata and atopic dermatitis regrow hair.

research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options

56 citations , January 2021 in “Clinical and Experimental Medicine”

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

research Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

56 citations , August 2020 in “American Journal of Clinical Dermatology”

New tools help assess eyebrow, eyelash, and nail changes in Alopecia Areata, improving understanding of patient experiences.

research Reactivation of Alopecia Areata After Dupilumab Therapy for Atopic Dermatitis

12 citations , August 2019 in “Dermatitis”

Dupilumab for skin problems might reactivate hair loss in some patients.

research Alopecia Areata in 2 Patients Treated with Dupilumab: New Onset and Worsening

26 citations , July 2019 in “JAAD Case Reports”

Dupilumab for atopic dermatitis may cause new or worsen existing alopecia areata.

research Dupilumab And Alopecia: A Janus Effect

29 citations , July 2019 in “Dermatologic Therapy”

Dupilumab can both heal and cause hair loss.

research Drug-Induced Alopecia After Dupilumab Therapy

49 citations , December 2018 in “JAAD case reports”

Dupilumab may cause significant hair loss, which can reverse after stopping the drug.

research Alopecia Areata After Dupilumab for Atopic Dermatitis

53 citations , January 2018 in “JAAD case reports”

Dupilumab for eczema may cause hair loss.

research Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata

39 citations , November 2017 in “Journal of The American Academy of Dermatology”

The document suggests using standardized methods to track and measure hair loss in alopecia areata, including patient self-assessment and a 50% improvement in specific scores as a treatment goal.