Serum Levels of Vitamin C, Vitamin E, and Total Antioxidant Capacity in Premature Graying Hair

    May 2026 in “ Archives of Dermatological Research ”
    Mohammadali Kerachian, Fatemeh Fazelifard, Amirali Reihani, Michael Saeed, Reyhaneh Fazeli, Amirhossein Derakhshan Doghaei, Nazanin Rasti, Zahra Hadavi, Seyyed Pouria Hosseini, Seyedeh Shabnam Mazloumi Kiapey, Bita Kiafar, Ahmad Reza Taheri, Seyed Isaac Hashemy
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    TLDR Genetics likely cause premature graying hair, not vitamin levels.
    This study investigated the relationship between serum levels of vitamin C, vitamin E, and total antioxidant capacity with premature graying hair (PGH) in 30 patients with PGH and 30 matched controls. The results showed no significant differences in these serum levels between the two groups. However, a strong association with family history was observed, suggesting a genetic predisposition to PGH. These findings indicate that genetic factors may play a crucial role in PGH, despite the lack of significant differences in oxidative stress markers, warranting further research into oxidative mechanisms.
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