Silk Fibroin Nanofibers-GelMA Hydrogel Composite Loaded with Embryonic Fibroblasts: A Strategy for Enhanced Wound Healing

The study developed a composite wound dressing using silk fibroin (SF) nanofibers and GelMA hydrogel, which significantly enhanced wound healing and hair follicle regeneration in mice. The GelMA/SF composite demonstrated superior mechanical properties, water retention, biocompatibility, and biological stability. In vitro studies showed that the composite promoted the viability and proliferation of mouse embryonic fibroblasts (MEFs), while in vivo application resulted in improved inflammation modulation, angiogenesis, collagen deposition, and re-epithelialization compared to GelMA alone. This innovative approach highlights the potential of GelMA/SF composites in advancing wound healing therapies.