Injectable Tissue Adhesive Composite Hydrogel With Fibroblasts for Treating Skin Defects

    January 2017 in “ Journal of Materials Chemistry B ”
    Feiyan Zhu, Chen Wang, Saina Yang, Qian Wang, Fuxin Liang, Chenyang Liu, Dong Qiu, Xiaozhong Qu, Zhongbo Hu, Zhenzhong Yang
    TLDR The hydrogel helps heal skin injuries by promoting blood vessel and hair growth.
    The study developed an injectable composite hydrogel by crosslinking glycol chitosan with silica nanoparticles, which served as a wound dressing with strong tissue adhesion properties. This hydrogel could be directly applied to wound sites, filling the area and acting as a carrier for proteins and cells. The encapsulation of fibroblasts within the hydrogel showed promising results in treating full-thickness skin defects in a mouse model, promoting the growth of hair follicles and microvessels, and reducing scar formation. The hydrogel demonstrated a lap-shear stretching force of approximately 90 kPa, indicating its strong adhesive capabilities.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results