Single-Cell RNA Sequencing Highlights the Role of Proinflammatory Fibroblasts, Vascular Endothelial Cells, and Immune Cells in the Keloid Immune Microenvironment

    October 2024 in “ International Journal of Dermatology ”
    Daishi Li, Zhaohuai Li, Sitao Liu, Xiaozhen Chen, Xiaozhen Chen, Xuanlin Che, Guangtong Deng, Jialing Chen, Li He, Rong Wang, Xiang Chen, Xiang Chen, Wenru Su, Juan Su
    TLDR Proinflammatory fibroblasts and vascular endothelial cells are key in keloid development.
    The study utilized single-cell RNA sequencing to investigate the immune microenvironment of keloids, focusing on proinflammatory fibroblasts (piF) and vascular endothelial cells (VEC). Analysis of three keloid lesions and two healthy skin samples revealed that piF and VEC are significantly elevated in keloid tissue. These cells are implicated in shaping the keloid microenvironment through increased expression of immune-associated genes and decreased expression of inflammatory chemokines. Additionally, VECs may act as a conditional immune subpopulation due to the upregulation of immune suppressive genes. The study also identified macrophages and Tregs as key players in the keloid immune landscape, suggesting potential therapeutic targets for keloid treatment.
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