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mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth
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5 / 801 resultslearn Stem Cell Factor
learn Neem Oil
natural substance from Neem tree with medicinal and pesticidal properties
learn Baricitinib
JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases
learn Hydrocortisone
a synthetic cortisol used for anti-inflammatory effects
Research
5 / 1000+ results research Single‐cell RNA sequencing highlights the role of proinflammatory fibroblasts, vascular endothelial cells, and immune cells in the keloid immune microenvironment
This study utilized single-cell RNA sequencing to investigate the immune microenvironment of keloids, analyzing tissue from three keloid lesions and two healthy skin specimens. The research identified proinflammatory fibroblasts (piF) and vascular endothelial cells (VEC) as key players in keloid development, with elevated levels in keloid tissue compared to normal skin. Differential gene expression analysis revealed increased expression of immune-associated genes and decreased expression of inflammatory chemokines in piF, while VEC showed upregulation of immune suppressive genes. The study also found enriched macrophage and Treg interactions, emphasizing macrophage-centered communication in keloids. These findings highlight the roles of piF and VEC in keloid pathology, suggesting new therapeutic targets.
research Metabolic disease with autoimmune phenomena: 2 cases of SLE-like disease in young children diagnosed with lysinuric protein intolerance
Two children with lysinuric protein intolerance showed symptoms similar to lupus.
research Transplantation immunology: Solid organ and bone marrow
Transplant success has improved with better immunosuppressive drugs and donor matching.
research Current and Potential Agents for the Treatment of Alopecia Areata>
Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.
research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege
CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.
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5 / 393 resultscommunity Is it possible to transplant mice skin into human body?
Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.
community Rate my MPB Genetics: Can I run Primobolan/Masteron? (Detailed MyHeritage DNA Data Included)
The user is using testosterone and finasteride to prevent hair loss and is considering adding Primobolan or Masteron, which are DHT-derivatives. They are seeking advice on their genetic risk for male pattern baldness and whether they can safely use these compounds without significant hair loss.
community Rethinking DHT and Hair Loss: Are We Targeting the Wrong Enemy?
Blocking DHT is not a cure for hair loss; instead, altering how scalp follicles respond to DHT might be more effective. Current treatments like topical finasteride and minoxidil are temporary solutions, and future approaches may involve gene therapy and bioengineering to change follicle behavior.
community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.
Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.
community DHT Harms Scalp Microbiome: DHT Itch is REAL
Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.