Smart Responsive Microneedles for Controlled Drug Delivery

The review discusses the development of smart responsive microneedles for controlled drug delivery, highlighting their ability to respond to various stimuli such as glucose levels, pH, temperature, and enzymes. These microneedles offer advantages like painless administration and targeted drug release, making them effective for conditions such as diabetes, wound repair, and cancer. The review emphasizes the use of different materials and fabrication methods, including glucose-responsive systems for insulin delivery and enzyme-responsive systems for targeted drug release. Despite challenges in safety and material stability, these microneedles show promise in improving drug delivery efficiency and specificity, with ongoing research aimed at enhancing their clinical application.