Single Nucleotide Polymorphisms in the KRT82 Promoter Region Modulate Irregular Thickening and Patchiness in the Dorsal Skin of New Zealand Rabbits

    May 2024 in “ BMC Genomics
    Bohao Zhao, Jiawei Cai, Xiyu Zhang, Jiali Li, Zhiyuan Bao, Yang Chen, Xinsheng Wu
    TLDR Certain genetic changes in the KRT82 gene may cause patchy skin in New Zealand rabbits.
    This study explores the genetic basis of irregular skin patchiness and thickening in New Zealand rabbits, focusing on the KRT82 gene. Researchers identified 592 differentially expressed genes, with KRT82 showing a significant correlation with hair follicle-related parameters. Four single nucleotide polymorphisms (SNPs) were found in the KRT82 promoter region, potentially influencing its expression and contributing to the patchiness phenotype. The study suggests that KRT82 could serve as a biomarker for breeding experimental rabbits and provides insights into the molecular mechanisms of skin phenotypes, aiding in the evaluation of skin irritation tests.
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