Classroom Practice of Social Studies Education Using Portfolios: Curriculum Reform and Teacher Competency Development (2)

The study investigated the efficacy of a bioconjugate nanoparticle, HA-P5, derived from fibroblast growth factors and conjugated with hyaluronic acid, in treating acne. HA-P5 was shown to significantly improve acne lesions and reduce sebum production by inhibiting fibroblast growth factor receptor 2 (FGFR2) and androgen receptor (AR) signaling. Unlike the commercial FGFR inhibitor AZD4547, HA-P5 did not induce the overexpression of AKR1C3, which can hinder acne treatment. The study highlighted the role of YTHDF3 in the signaling pathway between FGFR2 and AR, suggesting that HA-P5 could serve as an effective FGFR2 inhibitor for acne treatment.