SOCS1 and SOCS3 as Key Checkpoint Molecules in the Immune Responses Associated with Skin Inflammation and Malignant Transformation

SOCS1 and SOCS3 are crucial proteins that regulate immune responses by inhibiting the JAK/STAT signaling pathways, playing significant roles in skin inflammation and cancer. Their dysregulation is linked to inflammatory and autoimmune diseases, as well as cancer. Research has led to the development of SOCS-derived peptides and JAK inhibitors, which are used in treating conditions like psoriasis, atopic dermatitis, alopecia areata, and vitiligo. These proteins act as onco-suppressors, often silenced in tumors, affecting immune functions and tumor progression. The study highlights the therapeutic potential of targeting SOCS proteins in managing skin-related conditions and underscores the need for further research to enhance the efficacy of JAK inhibitors.