Increasing the Solubility of Minoxidil Using a Mixture of 1-Propanol and Water by the Shake Flask Method: Experimental Measurements, Thermodynamic Analyses, and Mathematical Modeling

Minoxidil effectively treats hair loss, especially androgenetic alopecia, but needs more research for better understanding.

10% minoxidil solution better promotes hair growth and reduces hair loss without significant side effects.

Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.

Minoxidil dissolves better in ethanol-water mixtures at different temperatures, with water playing a key role.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Minoxidil dissolves best in methanol and least in water.

A method was created in 2005 to identify minoxidil, a hair growth ingredient, in products using two types of capillary zone electrophoresis, and it found that most products had about 2% minoxidil.