Sorafenib-Induced Pityriasis Rubra Pilaris-Like Eruption: A Case Report

This case report describes a 22-year-old man who developed a pityriasis rubra pilaris (PRP)-like eruption after being treated with sorafenib for relapsed acute myeloid leukemia (AML). The patient presented with itchy skin lesions and was diagnosed with PRP through a skin biopsy. The Naranjo algorithm suggested sorafenib as the probable cause. Despite the skin reaction, sorafenib treatment was continued, and the patient was treated with vitamin A and topical agents, leading to improvement after one month. The report highlights the rarity of drug-induced PRP and the importance of recognizing such adverse effects without discontinuing essential chemotherapy.