Charting the Spatially Resolved Hair Follicle Stem Cell Niche: A Multi-Omics Atlas of Healthy and Diseased Scalp

November 2025 in “ Journal of Investigative Dermatology ”

Gokce Oguz, R. Phua, Zhi Wei Lim, N. Pantelireis, E Wang, Akilesh Ramasamy, Carlos Clavel

hair follicle stem cell niche androgenetic alopecia single-cell RNA sequencing spatial transcriptomics mesenchymal niches epithelial stem cells follicular miniaturization Stereo-seq intercellular signaling hair cycling hair regeneration AGA

TLDR Disrupted cell interactions in hair follicles contribute to hair loss in androgenetic alopecia.

The study integrates single-cell RNA sequencing and spatial transcriptomics to create a detailed atlas of the hair follicle stem cell niche in healthy individuals and those with androgenetic alopecia (AGA). By examining intercellular communication between mesenchymal niches and epithelial stem cells, the research identifies disrupted interactions during follicular miniaturization in AGA. The use of Stereo-seq allows for tissue-preserved, subcellular-resolution transcriptomics, identifying 27 distinct skin and hair follicle populations. This approach reveals altered intercellular signaling in AGA, providing new insights into hair cycling and regeneration, and lays the groundwork for developing therapies for hair loss disorders.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community When are we getting a cure to hair loss?

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Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 447 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

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PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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