SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis Through p53/Stem Cell Factor/C-KIT Signaling

    March 2024 in “ Journal of Investigative Dermatology ”
    Ying-Zhe Cui, Fan Xu, Yuan Zhou, Zhaoyuan Wang, Xing-Yu Yang, Ni-Chang Fu, Xi‐Bei Chen, Yuxin Zheng, Xueyan Chen, Li‐Ran Ye, Yingying Li, Xiao‐Yong Man
    TLDR SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.
    This study explores the impact of SPRY1 deficiency in keratinocytes on melanocyte stem cell (McSC) migration in mice. The absence of SPRY1 in keratinocytes triggers McSCs to migrate from hair follicles to the epidermis, causing skin hyperpigmentation through the p53/Stem Cell Factor (SCF)/C-KIT signaling pathway. This process mimics a tanning response and highlights the critical role of SPRY1 in regulating melanocyte behavior. Blocking the SCF/C-KIT pathway with an anti-C-KIT antibody reduced hyperpigmentation, confirming its role in McSC migration. The findings suggest that manipulating SPRY1 could be a potential therapeutic approach for skin pigmentation disorders.
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