Squamous Metaplasia Of The Prostate And Diffuse Alopecia In A 13-Year-Old Castrated Dog Due To Chronic Ingestion Of Exogenous Estradiol

    August 2012 in “ Open Repository and Bibliography (University of Liège) ”
    F. Van den Berghe, Jérôme Ponthier, Stéfan Deleuze
    TLDR A castrated dog developed hair loss and prostate issues from long-term exposure to estrogen cream.
    A 13-year-old castrated whippet exhibited generalized progressive alopecia and squamous metaplasia of the prostate due to chronic ingestion of exogenous estradiol from a transdermal cream. Despite previous treatment with trilostane and negative tests for Cushing disease, the dog's symptoms persisted. Clinical findings included an enlarged prostate and a suspected remaining cryptorchid testicle, which was later identified as an abscess. The dog's condition improved slightly with antibiotic treatment and surgery, but alopecia and some prostate issues remained due to prolonged estrogen exposure. The study highlighted the importance of considering exogenous estrogen sources in veterinary diagnostics.
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