Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischemia/Reperfusion

August 2020 in “ Research Square (Research Square) ”

Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang, Jin Fu

TLDR Hair follicle stem cells may help treat strokes by improving brain recovery.

The study investigated the potential of hair follicle stem cells (HFSCs) in treating ischaemic stroke using a rat model. HFSCs were intravenously administered to rats with induced middle cerebral artery ischaemia/reperfusion. The results showed that HFSCs migrated to the penumbra, expressed neuron-specific markers, reduced infarct volume, and promoted neurological recovery. These findings suggested that HFSC transplantation had therapeutic potential for ischaemic stroke and warranted further investigation for clinical development.

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Research cited in this study

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Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischemia/Reperfusion

Research cited in this study

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research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles