TLDR Skin organoids can model tuberculosis infection and help test treatments.
This study demonstrates that skin organoids (SKOs) derived from human induced pluripotent stem cells can effectively model cutaneous tuberculosis (CTB) infected by Mycobacterium tuberculosis (Mtb). The research reveals that Mtb infection in SKOs leads to an increase in fibroblasts, upregulation of collagen synthesis genes, and enhanced collagen degradation, which is linked to the destruction of nerve cells and adipocytes. The onset of fibrosis is driven by the activation of the PI3K-AKT signaling pathway and transcription factor AP1 in fibroblasts. Inhibiting PI3K-AKT and AP1 pharmacologically reduces fibrosis and collagen deposition. These findings highlight the potential of SKOs in studying CTB pathogenesis and testing antifibrotic treatments.
March 2025 in “Nature Communications” NSC167409 can effectively inhibit the virus causing hand, foot, and mouth disease.
1 citations
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September 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin organoids from stem cells can help study and treat skin issues but face some challenges.
14 citations
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May 2022 in “Stem cell reports” The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.
39 citations
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March 2022 in “Nature Protocols” Scientists created hair-growing skin models from stem cells, which could help treat hair loss and skin diseases.
20 citations
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November 2021 in “Frontiers in cell and developmental biology” Skin organoids from stem cells could better mimic real skin but face challenges.
31 citations
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January 2021 in “Experimental Dermatology” Skin organoids are a promising new model for studying human skin development and testing treatments.
425 citations
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June 2020 in “Nature”
9 citations
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August 2022 in “Frontiers in Pharmacology” Kangfuxin (KFX) extract speeds up wound healing and improves skin regeneration.
32 citations
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August 2024 in “Journal of Investigative Dermatology” In vitro skin models are improving but still need more innovation to fully replicate human skin.
August 2023 in “Military Medical Research” Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
November 2024 in “Burns & Trauma” Skin organoids help improve wound healing and tissue repair.
5 citations
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January 2021 in “Frontiers in cell and developmental biology” Skin cysts might help advance stem cell treatments to repair skin.
