Apoptotic Clearance by Stem Cells: Molecular Mechanisms for Recognition and Phagocytosis of Dead Cells

Stewart and colleagues' study, published in Nature, reveals how hair follicle stem cells (HFSCs) manage apoptotic cell clearance to sustain tissue health. The research highlights the ability of HFSCs to temporarily assume a phagocytic role at specific times, balancing this function with their regenerative duties. Key molecules involved in the sensing and engulfment of apoptotic cells by stem cells were identified, providing transformative insights into the molecular mechanisms underlying this process.