TLDR Nanoparticle delivery can reduce side effects of the cancer drug doxorubicin.
Streptomyces-derived doxorubicin (DOX) is a widely used anti-cancer drug effective against various cancers but is limited by significant adverse effects such as nausea, vomiting, alopecia, and cardiotoxicity. Nanoparticle delivery systems offer a promising solution to mitigate these side effects, with some formulations already in clinical use and others showing potential in development. This review emphasizes the importance of integrating nanotechnology with Streptomyces-derived compounds to enhance anti-cancer therapies, highlighting the current clinical status and the need for further development of multifunctional nanoparticles.
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