Review of Systemic Methotrexate Therapy in Pediatric Dermatoses

    January 2014 in “ Indian journal of paediatric dermatology ”
    Manjyot Gautam, Nitin Nadkarni, Sharmila Patil, Kiran Godse, Shweta Agarwal
    TLDR Methotrexate is effective and well-tolerated in children for certain skin conditions but requires careful monitoring.
    The review discussed the use of methotrexate (MTX) in treating various pediatric dermatoses, highlighting its cost-effectiveness and safety profile. MTX showed efficacy in conditions like psoriasis, atopic dermatitis, localized scleroderma, and juvenile dermatomyositis, with significant improvement in severe psoriasis cases and comparable results to cyclosporine in atopic dermatitis. Its efficacy in alopecia areata was variable. MTX was well-tolerated with manageable side effects, making it a viable option for pediatric dermatologic conditions. The review also debated the role of liver biopsy in monitoring MTX therapy, suggesting serum type III pro-collagen aminopeptide (PIIINP) as a potential alternative.
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