Tacrolimus Ointment: Summarizing Two Decades of Experience in Off-Label Use. Use in Rosacea, Seborrheic Dermatitis, Papulosquamous Dermatoses, Lupus Erythematosus, Eczematous Dermatoses, Alopecia, and Other Diseases

The document reviews two decades of off-label use of tacrolimus ointment for various dermatological conditions, including rosacea, seborrheic dermatitis, and alopecia. It highlights the ointment's efficacy in treating these conditions, particularly noting its role in managing alopecia, although studies involving 11 patients showed no significant hair regrowth. Tacrolimus is effective in areas like the face and genitals for psoriasis and is comparable to high-potency topical corticosteroids in treating oral lichen planus, with studies involving up to 965 patients. The review underscores the need for further research to understand its long-term effects and optimal usage, while recognizing its anti-inflammatory properties and lack of typical corticosteroid side effects.