Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds

This review examines the critical role of the Wnt/β-catenin signaling pathway in wound healing, particularly its involvement in the proliferative phase for granulation tissue formation. It highlights the pathway's transcriptional regulation of target genes and its interaction with the Notch and TGF-β signaling pathways. The review also addresses the deregulation of Wnt/β-catenin signaling in chronic wounds, with a focus on diabetic ulcers. Current and potential therapies targeting this pathway, including photobiomodulation, are discussed as strategies for improving healing in chronic wounds.