Topical Testosterone Induces Acne Pilosebaceous Alterations on Rat Skin

    January 2025 in “ International Journal Of Scientific Advances ”
    A.R. Maulana, Willy Sandhika
    TLDR Topical testosterone can cause acne-like skin changes.
    The study investigated the dermatological effects of uncontrolled topical testosterone application using 14 adult male Sprague-Dawley rats. Results showed that topical testosterone led to significant changes in the skin, including increased sebaceous gland size and hair follicle density, as well as dilated hair follicles filled with keratinous material, indicative of early acne lesions. These findings suggest that topical testosterone can induce acne-like alterations, highlighting potential dermatologic risks associated with Over-The-Counter (OTC) testosterone products and underscoring the need for stricter safety assessments and regulatory oversight.
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