Applications And Safety Of Testosterone Creams: A Systematic Review Of Topical Formulations, Clinical Efficacy, And Potential Risks

March 2026 in “ Seven Editora eBooks ”

Alberto Stoessel Sadalla Peres, Carolina Silva Peres, Celso Taques Saldanha, Rafael Pimentel Saldanha, Osvaldo Gonçalves da Silva Neto, Amanda Silva Peres, Bianca Silva Peres, Ana Paula Alves Da Silva, Alberto Stoessel Silva Peres, Ana Clara Barros Queiroz, Carolina Faria Leal Telino, Giulia Lisboa Cardoso Soares, Isadora Queiroz Presot, Júllia Eduarda Feijó Belluco, Vittoria Bethonico Foresti Roseo de Oliveira

testosterone creams testosterone gels testosterone ointments transdermal patches testosterone acne gynecomastia alopecia serum testosterone levels testosterone patches

TLDR Testosterone creams and gels can be effective but have serious risks and should be used only with medical supervision.

This systematic review evaluates the composition, mechanisms, efficacy, safety, and risks of topical testosterone formulations, such as creams, gels, ointments, and transdermal patches, used primarily by middle-aged and elderly men. The review, covering studies from 2010 to 2025, finds that while testosterone creams have variable absorption, gels provide stable bioavailability, and patches ensure continuous release. Despite their effectiveness in increasing serum testosterone levels, these formulations can lead to adverse effects like acne, gynecomastia, alopecia, and potential stimulation of prostate or breast cells. The study concludes that due to significant systemic risks, these products should only be used under strict medical supervision.

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