Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza Sativa L. Cv. Buebang 3 CMU and Sanpatong

November 2024 in “ Plants ”

Anurak Muangsanguan, Warintorn Ruksiriwanich, Chaiwat Arjin, Sansanee Jamjod, Chanakan Prom‐u‐thai, Pensak Jantrawut, Pornchai Rachtanapun, Patipan Hnorkaew, Apinya Sartsook, Mathukorn Sainakham, Juan Manuel Castagnini, Korawan Sringarm

rice bran extract Buebang 3 CMU Sanpatong ethanolic extract γ-oryzanol tocopherols antioxidant anti-inflammatory human hair follicle dermal papilla cells Wnt/β-catenin Sonic Hedgehog minoxidil finasteride rice bran Et-BB3-CMU

TLDR Et-BB3-CMU rice bran extract may be a promising natural option for promoting hair growth and preventing hair loss.

This study evaluates the hair growth promotion and anti-hair loss potential of rice bran extracts from Thai rice varieties Buebang 3 CMU and Sanpatong. The ethanolic extract of Buebang 3 CMU (Et-BB3-CMU) showed superior results, with high levels of bioactive compounds like γ-oryzanol and tocopherols, significant antioxidant and anti-inflammatory activities, and enhanced proliferation of human hair follicle dermal papilla cells. It effectively activated hair growth signaling pathways, such as Wnt/β-catenin and Sonic Hedgehog, and suppressed hair loss-related pathways more than standard treatments like minoxidil and finasteride. These findings suggest that Et-BB3-CMU could be a promising natural alternative for hair growth and hair loss prevention.

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