Research Advances in Therapeutic Strategies and Drug Delivery Systems for Pathological Scars

Recent advancements in therapeutic strategies for pathological scars focus on innovative drug delivery systems, such as microneedles, hydrogels, and nanoplatforms, which enhance the efficacy of treatments by targeting specific signaling pathways involved in scar formation. These systems, including biomaterial-based delivery methods like nanoparticles, offer sustained and targeted drug delivery, improving outcomes for conditions like keloids and hypertrophic scars. Promising therapies include TGF-β pathway inhibitors, photodynamic therapy, and regenerative medicine using stem cells. Despite these advancements, challenges remain in clinical translation, necessitating further research and large-scale clinical trials to confirm efficacy and safety.