Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems, and Individualized Dosing

January 2024 in “ Frontiers in Pharmacology ”

Lin Zhao, Jia‐Mei Chen, Bai Bai, Gyeongju Song, Jingwen Zhang, Yu Han, Shiwei Huang, Zhang Wang, Guanghua Lu

topical drug delivery skin barrier stratum corneum transdermal absorption

TLDR Improving topical drug delivery involves overcoming skin barriers and using personalized dosing to enhance effectiveness.

The document explores strategies to enhance topical drug delivery by addressing skin barriers, utilizing advanced drug delivery systems, and implementing individualized dosing. It discusses innovative carriers like cell-penetrating peptides, polymers, and bacteria-based systems, each offering unique benefits and challenges. The paper highlights the role of drug-smart response elements and factors affecting transdermal absorption, such as molecular weight and skin hydration. It emphasizes the potential of personalized medicine, considering genetic and microbial factors, to improve drug efficacy and reduce side effects. Despite advancements, the document concludes that achieving precise individual medication for topical drugs requires further research, particularly in understanding skin penetration and optimizing drug delivery systems.

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Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems, and Individualized Dosing

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