Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review

The systematic review analyzed the therapeutic applications of botulinum neurotoxins (BoNTs) in dermatology, highlighting both established and off-label uses. BoNTs were found to have several dermatological applications, with the strongest evidence supporting their use in treating focal idiopathic hyperhidrosis. Other conditions where BoNTs showed potential included Raynaud phenomenon, alopecia, psoriasis, and Hailey–Hailey disease, among others. The review emphasized the need for further clinical trials to better understand the efficacy and safety of these applications and to standardize injection and dosage protocols for off-label uses. Overall, BoNT-A demonstrated varying degrees of effectiveness across different dermatological conditions, with more robust evidence required for widespread clinical application.